ViroCell Biologics and Great Ormond Street Hospital for Children Announce Partnership to Dislodge Gene and Cell Therapy “Logjam”
ViroCell Biologics (“ViroCell”), founded by the UK’s most prolific academic viral vector manufacturing team, and Great Ormond Street Hospital for Children NHS Foundation Trust (“GOSH”), a world leading children’s hospital, have today announced a new partnership that will immediately address the global viral vector manufacturing bottleneck for clinical trials.
ViroCell, an innovation-driven Contract Development and Manufacturing Organization (“CDMO”), is addressing the global viral vector supply demand imbalance that constrains the manufacture of novel cell and gene therapies. ViroCell focuses exclusively on the design and GMP manufacture of viral vectors and gene modified cells for clinical trials. ViroCell aims to be the global viral vector supplier of choice during the translational phase of development of novel cell and gene therapies.
Viral vectors are high-value delivery vehicles used to make cell and gene therapies, and their availability and effectiveness governs the clinical success of the treatment. ViroCell is focused where the viral vector design and GMP manufacturing bottleneck is most acute: the zone between pre-clinical concept and pivotal clinical trials. ViroCell is therefore filling the gap between “small volume” academic core labs and “large volume” contract development and manufacturing organizations (“CDMOs”).
As part of the partnership with GOSH, ViroCell will more than double the UK’s lentivirus vector manufacturing capacity for clinical trials in 2022 and secure the coveted position as the first UK CDMO to be able to deliver AAV vectors to the cell and gene therapy (“CGT”) markets.
The production of the vectors will take place in GOSH’s Zayed Centre for Research into Rare Disease in Children. The ViroCell team’s track record of manufacturing more than one hundred viral vectors for clinical trials over the last 20 years coupled with the Zayed Centre for Research’s state-of-the-art clean room suites will enable ViroCell and GOSH to dislodge the logjam that currently prevents promising, novel cell and gene therapies from entering clinical trials.
While commercial-scale CDMOs operate at batch scales between 200L and 2,000L, ViroCell is regarded as the European vector CDMO of choice in the 1L to 200L batch size based on its deep prior experience and in-licensed, validated production technology platforms. ViroCell’s team built one of Europe’s most productive academic core labs before spinning out in 2020 and is now supported by a prolific Scientific Advisory Board of internationally leading innovators.